PURPOSE: Adductor-type laryngeal dystonia (AdLD) is a voice disorder with substantial negative effects. The current standard treatment is botulinum toxin (BoNT) injections, with novel treatments on the horizon. The aim of this study was to determine the sensitivity of selected acoustic measures to measure voice quality change from pre-BoNT to the participants' perceived maximum benefit from BoNT. METHOD: Twenty-three participants with AdLD underwent acoustic recordings at pre-BoNT and a subset o...

This study explores how DBS Group, a mid-sized Bangladeshi ready-made garments (RMG) exporter, implements digital transformation technologies—Internet of Things (IoT), blockchain, and Enterprise Resource Planning (ERP)—to enhance supply chain efficiency. Using an exploratory single-case study, secondary data from BGMEA (2024), McKinsey (2021), and Textile Network (2023) were synthesized, with inferred metrics (e.g., 10–15% lead time reduction) benchmarked against RMG standards. Findings show IoT

BACKGROUND: Perinatal hypoxic-ischemic encephalopathy (HIE) is a severe condition resulting from impaired oxygen delivery to the developing brain, often leading to both motor deficits and dystonia-dyskinetic syndromes (DDS). In selected cases, deep brain stimulation of the globus pallidus internus (GPi-DBS) may provide a therapeutic option. However, predicting outcomes remains challenging because of clinical heterogeneity and variable responses. OBJECTIVES: This retrospective study aims to ident...

OBJECTIVE: Intrathecal baclofen (ITB) pumps are essential for managing spasticity and dystonia in children; however, they carry risks of hardware infection, withdrawal syndrome, and emergent failure. Management of these complications remains variable across institutions, and no unified, pediatric-specific workflow exists to date. We sought to develop and implement standard work tools (SWTs) to guide the evaluation and treatment of ITB pump infection and withdrawal in pediatric patients. METHODS:...

Complex regional pain syndrome (CRPS) with associated dystonia is a severely debilitating condition often refractory to conventional management. We present a case report of three patients with chronic, treatment-refractory CRPS-related limb dystonia. Patients were treated with multiday intravenous ketamine infusions (target dose 30 mg/hour) every 3-6 months, supplemented with oral ketamine troches. This treatment protocol resulted in the complete resolution of dystonia in two patients and signif...

A woman with complex psychiatric illness and substance use disorder presented with nausea, vomiting, and episodes of oculogyric crisis. A medication review suggested drug-induced acute dystonia, likely triggered by metoclopramide. Other symptoms were possibly related to cumulative anticholinergic effects. Fluoxetine, a potent CYP2D6 inhibitor, may have increased exposure to metoclopramide and promethazine. This case report demonstrates that pharmacological insight and deprescribing can improve s...