Putamen Atrophy as a Predictive Factor of Efficacy of GPi-DBS in Dystonia-Dyskinesia Syndrome Secondary to Perinatal Anoxic Encephalopathy.
| Authors | Grasso Marylou, Moser Pierre-Olivier, Sauvageot Sidonie, Gil Valérie, Chan-Seng Emilie, Sanrey Emily, Coubes Philippe, Poulen Gaëtan |
|---|---|
| Journal | Mov Disord |
| Published | 2026 Mar 18 |
| PMID | 41851006 |
| DOI | 10.1002/mds.70275 |
| Source | PubMed |
| Digest | Digest #2 |
Abstract
BACKGROUND: Perinatal hypoxic-ischemic encephalopathy (HIE) is a severe condition resulting from impaired oxygen delivery to the developing brain, often leading to both motor deficits and dystonia-dyskinetic syndromes (DDS). In selected cases, deep brain stimulation of the globus pallidus internus (GPi-DBS) may provide a therapeutic option. However, predicting outcomes remains challenging because of clinical heterogeneity and variable responses. OBJECTIVES: This retrospective study aims to ident...