Dystonia Research Digest

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Long-term relief of CRPS-associated limb dystonia with ketamine infusion.

PubMed DOI: 10.1136/bcr-2025-269687 Dystonia Pain
AuthorsAlZahrani Abdulrahman, Weber-Adrian Danielle, Ong May C
JournalBMJ Case Rep
Published2026 Mar 19
PMID41856690
DOI10.1136/bcr-2025-269687
SourcePubMed
DigestDigest #2

Abstract

Complex regional pain syndrome (CRPS) with associated dystonia is a severely debilitating condition often refractory to conventional management. We present a case report of three patients with chronic, treatment-refractory CRPS-related limb dystonia. Patients were treated with multiday intravenous ketamine infusions (target dose 30 mg/hour) every 3-6 months, supplemented with oral ketamine troches. This treatment protocol resulted in the complete resolution of dystonia in two patients and signif...
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